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With a long experience in evaluating public health measures in the fields of HIV and drug addiction at national level, the Evaluation and Expertise in Public Health sector (CEESAN, Unisanté, Switzerland) has also been monitoring the situation in the canton of Vaud for more than twenty years. In this article, we present two instruments developed for epidemiological monitoring purposes the « Pointage annuel du profil des usager·ère·s des structures à bas-seuil d'accès » (PAPU, annual measure of users of low-threshold facilities' profile) an