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Kaplan-Meier postoperative survival curves demonstrated that the low expression of PRDM5 was associated with poor prognosis in patients with glioma. In addition, suppression of PRDM5 promoted cell proliferation via regulating cell cycle progression. Finally, knocking down PRDM5 using small interfering RNA decreased the apoptosis of glioma cells.Conclusion Taken together, these findings suggested that PRDM5 may be a novel therapeutic target of glioma.Aortic aneurysm is a permanent focal dilation of the aorta. It is usually an asymptomatic