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The above results provide insights into the designs, applications and risk assessments of nanomaterials by the surface atomic arrangement regulation. Six prospective real-world studies of antihypertensive treatment with valsartan-centric regimens were pooled to (1) examine the effectiveness of ∼90 days of second- or later-line valsartan treatment in hypertensive patients with known comorbidities; and (2) identify physician- and patient-related determinants associated with systolic (SBP) and diastolic blood pressure (DBP) outcomes in the