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To investigate the expression and clinical significant of VCAN and its related molecules in patients with MM. Ficoll density gradient centrifugation method was used to speared the bone marrow mononuclear cell in 25 cases of MM before and after treatment, the relative mRNA expression of VCAN and their related molecules (FAK, FN, MK, and HAS) in bone marrow was detected by real-time quantitative PCR, and their protein expression was determined by Western bolt. The expression of VCAN, FK and FN in the effective group after treatment was sig