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How to Choose the Best ADHD Medication for Adults With Anxiety and Depression When a person suffers from both ADHD and anxiety or depression, treating the first disorder can improve the second. Mental health professionals typically prescribe antidepressants or stimulants for depression, along with an ADHD medication. Wellbutrin (bupropion), and Effexor, (venlafaxine), are the two most commonly used antidepressants that are prescribed for ADHD "off-label". These medications boost levels of neurotrans