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Genetic factors have a role in response to a target medication (personalized medicine). This study aimed to review available evidence about the relationship between gene variants and therapeutic response to sulfonylureas in type 2 diabetes, systematically. An extensive search was done in Scopus, PubMed, and Web of Science with specific search strategy in the field from the beginning until the 1 of Jan. 2021. After sending records to endnote software and removing duplicate records remained documents were screened by title and abstract. Fu