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The effectiveness and safety of ultrasound-guided needle-knife in the treatment of De Quervain's disease were evaluated with pain intensity, wrist function as the main index and wrist range of motion, adverse events and quality of life as the secondary index. Revman5.3 software was used for data processing. This study will provide the latest evidence for the Ultrasound-guided needle-knife for De Quervain's disease. The conclusion of this study is to evaluate the effectiveness and safety of ultrasound-guided needle-knife in the treatment o