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2%; precision 97.1%; AUC 0.958). For MS prognosis, our model with a 3-year follow up to predict disability progression 8 years later was the best predictive model. DT performed best for fast macular thickness protocol (accuracy 91.3%; sensitivity 90.0%; specificity 92.5%; precision 92.3%; AUC 0.913) and SVM for fast RNFL-N thickness protocol (accuracy 91.3%; sensitivity 87.5%; specificity 95.0%; precision 94.6%; AUC 0.913). This work concludes that measurements of RNFL thickness obtained with Spectralis OCT have a good ability to diagnos