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RESULTS Low dose frankincense and myrrha increased cell proliferation and migration in HUCs compared with control (P less then 0.05). Rats with acute IC/PBS rats exhibited lower voiding interval values, pain tolerance, and ZO-2 expression (P less then 0.05). Voiding interval values and pain tolerance were higher in the frankincense and myrrha group than CYP group (P less then 0.05). ZO-2 expression in the bladder was increased in the CYP + pentosan polysulfate and frankincense + myrrha groups compared with the CYP-induced acute IC/PBS g