https://www.selleckchem.com/pr....oducts/bix-01294.htm
29, 95% credible interval [CrI] 1.22 to 4.25), 200 mg/day (RR=4.35, 95%CrI 2.31 to 8.01) and 300 mg/day (RR=6.02, 95%CrI 3.22 to 11.1) involved a higher risk of gastrointestinal AEs. Similarly, tramadol 100-300 mg/day showed a higher risk of CNS AEs and withdrawals. However, the risk of cardiovascular AEs remained unclear. Only tramadol 300mg/day showed minimal improvement in pain and function but with increasing AEs compared with placebo. Tramadol may not be sufficiently recommended for knee or hip OA by presented evidence, especiall
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