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elegans. Early, accurate diagnosis and timely treatment with drainage of the abscess and long-term administration of antimicrobial agents optimize the outcome.Dinoflagellate-derived polyketides are typically large molecules (1000 Da) with complex structures, potent bioactivities, and high toxicities. Their discovery suffers three major bottlenecks insufficient bioavailability, low-yield cultivation of producer organisms, and production of multiple highly related analogues by a single strain. Consequently, the biotechnological production of thera