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12 (versus patients with a HR-CV 0.08 as a reference) was 1.73 (95% CI, 1.11-2.7 for an unfavorable outcome. Our results indicated that a high initial in-hospital HR was significantly associated with unfavorable 3-month functional outcomes in patients with AIS. In addition, stroke patients with a HR-CV ≥ 0.12 also had unfavorable outcomes compared with those with a HR-CV 0.08 if they had a history of hypertension. Our results indicated that a high initial in-hospital HR was significantly associated with unfavorable 3-month