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Noninvasive choices, such closed-circuit acetylene (C2H2) rebreathing, warrant validation. Techniques and Results We examined 10 clinical researches and all sorts of available cardiopulmonary stress checks done inside our laboratory that included a rebreathing method and direct Fick or thermodilution. Researches included healthy individuals and customers with clinical infection. Simultaneous cardiac production measurements were acquired under normovolemic, hypovolemic, and hypervolemic problems,