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Systolic durations, estimated by each of the end systole estimates, are then compared to the validation systolic duration provided by the PTT based end systole point. Data comes from ten pigs, across two protocols testing the algorithms under different hemodynamic states. The resulting mean difference ± limits of agreement between measured and estimated systolic duration, of [Formula see text] versus [Formula see text], for the new and existing algorithms respectively, indicate the new algorithms superiority.BACKGROUND Cockayne syndrom