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I read with this informative review article by Cheng et al. " Organ-protective effect of angiotensin-converting enzyme 2 and its effect on the prognosis of COVID-19". I would like to talk about the role of ACE2 in endothelial cell function. Besides, I would like to mention that COVID-19 patients might benefit from ACEI/ARBs concerning improving endothelial dysfunction in COVID-19. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.PURPOSE To evaluate the quantitative ima