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001) had more MPCs than those who never received RT or CT. Survival in MPCs was worse than in single primary cancers. The 5- and 10-year survival rates were 28.1%, and 12.4%, respectively. Conclusion We identified approximately 5% MPCs among 117,139 patients in our database. MPCs are more common at 60-69 years in males and at 50-59 years in females. In terms of the risk of MPCs, we should be aware of the cancers that have risk factors, habits, and genetic features commonly affecting primary cancers.Purpose Sea macroalgae are an importa