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1μmol/L (1.0mg/dL) and CV is maintained≤10%. A specificity 70% for predicting 75th percentile bilirubin values was observed when positive systematic bias was 17.1μmol/L (1mg/dL) or less at CV≤10%. Critical errors did not occur with a frequency 0.2% until negative bias was -17.1μmol/L (-1mg/dL) or lower. A positive systematic bias of 17.1μmol/L (1mg/dL) may be optimal for balancing sensitivity and specificity for predicting ≥75th percentile TSB values. Negative systematic bias should be avoided to allow detection of high risk