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ar vesicles secreted from AD patient derived neurons contain a relatively low amount of Aβ but have an increased Aβ42/ Aβ40 ratio; the majority of Aβ is located on the surface of the EVs. The results of our research can contribute substantially to the successful translation of stem cell biology into clinical therapy by improving our understanding of the pathogenesis and treatment of Alzheimer's disease.Neurodegenerative diseases lead to the death of nerve cells in the brain or the spinal cord. A wide range of diseases are included with