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Zoledronate infusion resulted in BMD enhance. Bone participation can present with diverse severity in the same pedigree, which range from low BMD to multiple fragility cracks. Antiresorptive therapy improves BMD, but its anti-fracture efficacy continues to be becoming shown. The current presence of CD might show the significant part of NOTCH2 signaling in different tissues.Bone involvement can present with diverse extent in identical pedigree, ranging from reasonable BMD to multiple fragility c