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Although the patient had a number of surgical site complications, such as wound dehiscence, and superficial and deep infections due to vulnerable skin in HGPS, no recurrence or metastases were detected for 13 years, and she walks assisted by crutches. Her general health was good at the latest follow-up at 31 years of age. A HGPS patient with osteosarcoma was successfully managed and she was alive 13 years after the diagnosis. A HGPS patient with osteosarcoma was successfully managed and she was alive 13 years after the diagnosis. Rectal