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The mainstream interventions used during the 2014-2016 Ebola epidemic were contact tracing and case isolation. The Ebola outbreak in Nigeria that formed part of the 2014-2016 epidemic demonstrated the effectiveness of control interventions with a 100% hospitalization rate. Here, we aim to explicitly estimate the protective effect of case isolation, reconstructing the time events of onset of illness and hospitalization as well as the transmission network. We show that case isolation reduced the reproduction number and shortened the serial i