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To investigate if depression risk modifies the association between frailty and mortality in older adults. Ongoing cohort study. Albacete city, Spain. Eight hundred subjects, 58.8% women, over 70 years of age from the Frailty and Dependence in Albacete (FRADEA) study. Frailty phenotype, Geriatric Depression Scale (GDS), comorbidity, disability, and drug use were collected at baseline. Six groups were categorized (G1 non-frail/no depression risk; G2 non-frail/depression risk; G3 prefrail/no depression risk; G4 prefrail/depression risk; G5