https://www.selleckchem.com/pr....oducts/Clofarabine.h
Western blotting showed that DMC reduced the levels of p-EGFR , GRB2, Sos1, p-Raf, MEK, p-ERK1/2, PI3K, p-Akt/PKBα , p-PDK1, NF-κB, TIMP-1, MMP-9, MMP-2, GSK3α/β, β-catenin, N-cadherin, and vimentin, but it elevated Ras and E-cadherin at 24 h treatment. DMC inhibited cancer cell migration and invasion through inhibition of PI3K/Akt and NF-κB signaling pathways in GBM 8401 cells. We suggest that DMC may be used as a novel anti-metastasis agent for the treatment of human glioblastoma cancer in the future. DMC inhibited cancer cell mig
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