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We further confirmed this finding in a standard fed-batch production assay. Sodium chlorate at 16mM markedly inhibited tyrosine sulfation by more than 50% and had no significant impact on antibody titer or quality. These data suggest that we can control tyrosine sulfation by selecting CHO cell lines based on the expression level of TPST2 and SLC35B2 or adding sodium chlorate in upstream production process. These data suggest that we can control tyrosine sulfation by selecting CHO cell lines based on the expression level of TPST2 and SLC35
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