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The paper explores the contribution that theories of large-scale transformation can make to the design of palliative and end of life care services in health and social care. The paper explores the contribution that theories of large-scale transformation can make to the design of palliative and end of life care services in health and social care.Background . Hashimoto's thyroiditis (HT) is an auto-immune condition characterized with lymphocytic and fibroblastic infiltration of the thyroid gland. The rate of uric acid and HDL cholesterol; so called as