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This research found that the pairs of genes , , , , and are functionally related. Furthermore, two differentially expressed gene pairs ( and ) are involved in the vascular endothelial growth factor receptor signaling pathway and the purine ribonucleoside diphosphate metabolic process, respectively. This research found that the combination of computational analysis and laboratory data provided the opportunity to better characterize the relation between central colorectal cancer genes as well as possible pathways involved in the colorecta