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The detection was performed on a triple quadrupole tandem size spectrometer by several effect monitoring (MRM) mode in good ionization mode with transitions at m/z 376.29 → 165.14 and m/z 380.28 → 169.17 for haloperidol and haloperidol-d4 (used as an internal standard), respectively. The method ended up being fully validated to cover large concentration range of 0.05-80 ng/mL in person plasma and satisfies the criteria for the selectivity, linearity and reduced restrictio
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