https://inhibitorlibraries.com..../a-new-membrane-teth
Here we identify COP1 as the ubiquitin E3 ligase this is certainly required for LT-induced c-Jun degradation. COP1 knockdown using siRNA prevents degradation of c-Jun, ETV4, and ETV5 in cells treated with either LT or perhaps the MEK1/2 inhibitor, U0126. Immunofluorescence staining reveals that COP1 preferentially localizes to your nuclear envelope, however it is circulated through the nuclear envelope to the nucleoplasm after Erk1/2 inactivation. At basel
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