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for systemic and structural interventions is clearly indicated, including open and supportive organisational cultures, leadership development and adequate staffing. Data on the magnitude of benefit of modern therapies for pulmonary arterial hypertension (PAH) in connective tissue disease (CTD)-associated PAH are limited. In this study, we performed meta-analyses of randomized, controlled trials (RCTs) and registries to quantify the benefit of these modern therapies in patients with CTD-PAH. The PubMed and Embase databases were searched
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