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How Does ADHD Medication Work? When one neuron sends a message to another neuron, it makes use of neurotransmitters, chemicals. need to cross a tiny gap called a synapse. Some ADHD medications boost the effectiveness of these messages. They either aid neurons in releasing more neurotransmitters or slow down the reuptake process (called Reuptake inhibitors). Doctors put patients suffering from ADHD with a low dose of medication and observe their reactions. They alter the dos