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Specifically, for the mean Dice ratio of all 10 subjects, the proposed method achieved 95.14%±0.9%, 90.17%±1.83%, and 81.96%± 4.32% for WM, GM, and CSF. With the experiment results, the proposed algorithm can achieve better performances than other automatic segmentation methods. Further experiments are performed on the 200 3T1.5T brain MR images of ADNI dataset and our proposed method shows promised performances. The authors have developed and validated a novel fully automated method for 3T brain MR image segmentation. The authors h