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112; 95% confidence interval [CI] 0.001-0.944; = 0.043) and increased rebleeding (HR = 8.39; 95% CI 1.13-62.29; = 0.037). The time-dependent Cox model showed evidence for a reduction in a composite (thrombotic events, bleeding, and death) attempting to capture net benefit (HR = 0.384; 95% CI 0.161-0.915; = 0.031). This analysis provides modest evidence that restarting anticoagulation in factor Xa inhibitor-associated major bleeding patients is correlated with reduced risk of thrombotic events and increased risk of rebleeding. There
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