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ADHD Medications - Stimulant Or Non Stimulant? Stimulant drugs are the most popular ADHD treatment, because they are the most researched and have the fastest-acting effects. However, they're not for everyone. These medications boost signaling between nerves and regions in the brain to lessen symptoms of ADHD. These medications can also trigger side-effects like a change in blood pressure or heart rate and the loss of appetite. Stimulants The most commonly used medication to treat AD