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6% (7/11) and 83% (10/12), respectively. However, these differences were not statistically significant. Conclusion The effectiveness and safety of PED for LGVBAs is acceptable. Treatment results did not differ between the PED and PED with adjunctive coils groups; therefore, whether coils should be used may depend the operator. Our results suggest that correct use of the coils does not increase complications. We suggest that PED with adjunctive coils should be used for some selected LGVBAs.Biotinidase deficiency is an autosomal recessive d