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The management of locally advanced extremity soft structure sarcomas, particularly in regards to a limb salvage method, presents a challenge, particularly in recurrent tumors. Within the context of a patient-tailored multimodal therapy, hyperthermic remote limb perfusion (ILP) is a promising limb-saving treatment option. We report the results of customers with mainly irresectable and locally recurrent smooth tissue sarcoma (STS) addressed by ILP. Data about patient demographics, clinica