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25, 0.5, and 0.75 mm were -5.4%, -7.3%, and -13.1%, respectively. The mean absolute errors were 13.6 mm , 15.7 mm , and 18.2 mm , respectively. The section thickness values of CBCT images can be increased to a reasonable level to obtain accurate volume estimation results and save time. The semiautomatic segmentation method can be used reliably for volume estimations of bone defects. The section thickness values of CBCT images can be increased to a reasonable level to obtain accurate volume estimation results and save time. The semiauto