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These results revealed that structural abnormality exists in NMO female patients who have pain, with significant implications for our understanding of the brain morphology in NMO patients with pain. BACKGROUND To systematically review and synthesize the literature on the multiple sclerosis (MS) gut microbiota composition as compared to persons without MS. METHODS We systematically searched MEDLINE, EMBASE, and Web of Science databases for relevant published articles (2008-2018). RESULTS Of 415 articles identified ten fulfilled criteria. All studies used a c