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ould provide a treasure trove, which will accelerate the development of new antidepressants that can effectively improve cognitive symptom in MDD. Studies on their molecular mechanisms may provide more potential targets and therapeutic approaches for new drug discovery. ETHNOPHARMACOLOGICAL RELEVANCE The alcoholic liver injury (ALI) commonly occurs among people, typically the young and the middle-aged, who drink heavily. The ALI is extremely harmful and can induce severe disease states such as hepatitis, liver fibrosis, cirrhosis or even liver cancer. Recen