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Endemic relapsing fever (RF) is one of the most important arthropod-borne diseases caused by various types of Borrelia and transmitted by soft tick species. The investigation of the distribution of vectors in a region can help control and prevent the disease. This study aimed to investigate the distribution of Ornithodoros tholozani and Ornithodoros lahorensis in Iran and to identify the most influential climatic variables affecting their distribution. The ecological niche model was used in Maxent to predict the environmental suitabili