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ADHD Medications - Stimulant Or Non Stimulant? Stimulant drugs are the first-choice ADHD drugs, with the most research-based backing behind them, and are quick-acting. But they're not for everyone. These medications enhance the signaling between nerves and brain regions to lessen ADHD symptoms. They can also have adverse effects such as an appetite loss and changes in heart rate or blood pressure. Stimulants The most common medication used to treat ADHD is stimulants. They are known for