https://www.selleckchem.com/pr....oducts/sar131675.htm
Silver-promoted C-F bond formation in α-bromoamides by using AgF under mild conditions is reported. This simple method enables access to tertiary, secondary, and primary alkyl fluorides involving biomolecular scaffolds. This transformation is applicable to primary and secondary amides and shows broad functional-group tolerance. Kinetics experiments revealed that the reaction rate increased in the order of 3°2°1° α-carbon atom. In addition, it was found that the acidic amide proton plays an important role in accelerating the re
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