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How Does ADHD Medication Work? When a neuron transmits a signal to another, it makes use of neurotransmitters, which are chemicals that act as. They need to travel through a tiny gap known as the synapse. Certain ADHD medications can make the passing along of these messages more efficient. They either help neurons release neurotransmitters faster or slow the Reuptake (called reuptake inhibiters). Doctors put patients suffering from ADHD with a low dose of medication and then observe their responses