https://plkpathway.com/study-t....he-treating-fatty-sl
The monolayer permeability of bEnd.3 cells, as well as the mRNA level and protein phrase of tight junction proteins (TJs), including Claudin 5, Occludin, and ZO-1, were analyzed. In addition, the inhibition of Aβ(25-35)-induced NLRP3 inflammasome activation, as well as the autophagy caused by LSP had been examined by finding the appearance of NLRP3, caspase-1, ASC, LC3, AMPK, mTOR, and ULK1. Also, the cognitive purpose therefore the appearance of TJs, NLRP3, caspase-1, IL-1β, and p62 were determined in APP/PS1 mice.
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