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Right here, we've identified a few small-molecule fusion inhibitors, directed by a neutralizing antibody, against an extensively studied vaccine target-the membrane proximal exterior region (MPER) of the HIV-1 envelope surge. These compounds specifically inhibit the HIV-1 envelope-mediated membrane fusion by blocking CD4-induced conformational changes. An NMR structure of just one element complexed with a trimeric MPER construct shows that the chemical partially inserts into a hydrophobic pocket f
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