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The NRI and IDI for the 3-year overall survival indicated that the model with the immune scores was superior for classifying the risk probability and distinguishing cases. Immune scores may be an independent predictor of prognosis in patients with ESCC. Immune scores may be an independent predictor of prognosis in patients with ESCC.The hypertension (HTN) and type 2 diabetes mellitus (T2DM) are a common multifactorial disease due to genetics and environmental factors. The alpha 2B adrenergic receptor (α2B-AR) has relationship with secr