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Indeed, preserving their task in the long run is a must for optimizing the employment of health sources.SIGNIFICANCE It is well established that lifestyle and nutritional habits have a significant affect lifespan, the price of aging plus the onset/progression of age-related diseases. Especially, nutritional restriction (DR) as well as other healthy dietary patterns usually are accompanied by physical activity and differ to west diet that will be abundant with fat and sugars. Moreover, while the generat