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Baseline sIgE levels were significantly low in children achieving 25mL STU. Continued fixed LOIT yields immunologic improvement and may be effective and safe for severe CM allergy. Continued fixed LOIT yields immunologic improvement and may be effective and safe for severe CM allergy.The outbreak of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has become a global crisis. As of November 9, COVID-19 has already spread to more than 190 countries with 50,000,