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The incidence of pain in the group that received the classical incision (A) was 20% (n=4) and in group B was 35% (n=7). CONCLUSIONS We found a higher rate of post-craniectomy headache in patients who underwent a "modified Dandy" incision. These are preliminary data of an undergoing study and we hope to obtain more representative information in the future. We recommend interdisciplinary follow up for the integral treatment of PCH. OBJECTIVE To investigate the role of Spam1 hyaluronidase in age-related bone and cartilage changes in the mouse