https://www.selleckchem.com/pr....oducts/actinomycin-d
The cryptolactones A1, A2, B1, and B2 isolated from a Cryptomyzus sp. aphid were synthesized via the Mukaiyama aldol reaction and olefin metathesis. Their antipodes and derivatives were also synthesized by the same strategy to investigate structure-activity relationships. These compounds exhibited cytotoxic activity against human promyelocytic leukemia HL-60 cells with IC50 values of 2.1-42 µM.Tyrosinase plays important roles in many different disease related processes, and the development of its inhibitors is particularly importa
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