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On multiple stepwise regression analysis, FEV1 at age 6 was found to be the only independent predictor of mortality (adjusted odds ratio [95% CI] 0.5 [0.3-0.8]; P = .005). CONCLUSION FEV1 at age 6 was an independent predictor for CF-related mortality. Measurement of lung function in preschool children in SA with CF using more sensitive methods than spirometry is important to identify children at risk of poor outcomes. © 2020 Wiley Periodicals, Inc.AIM Protracted bacterial bronchitis (PB is considered a potential precursor to bronchiecta